I have no idea to be honest. This is not something I ever thought about but I don’t think so. Some beauty products already contain nano-particles as they can produce nice colours but I cannot see it preventing wrinkles. Acne is another thing, but I think we’ll have to look to the pharmacists for that.
What benefit do you hope to gain from blue or gold skin? We need our skin to absorb sunlight for making Vitamin D so I think a reflective golden skin would be highly disadvantageous. Maybe you should stick to body paint or, in an extreme case, tattoos.
There is already some nano-particles in face creams that are anti-wrinkle. The main reason these are used in face cream is because they are so so tiny they are easily rubbed into the skin. I haven’y used any anti-wrinkle cream (just yet) so I am not sure if it works.
They could possible be used in creams for acne for the same reason that they are easily rubbed into the skin.
If something was going to change the colour of your skin to blue or gold they would not be allowed put this to market.